The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.
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Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion patterns of variant repeats along the array, which provides details on the structure of the alleles before and after mutation. From Wikipedia, the free encyclopedia. Please help us clarify the article. Close mobile search navigation Article navigation.
Additional analyses of DNA sequences flanking human minisatellites have also revealed an intense and highly localized meiotic crossover hotspot that is centered upstream hypervwriable the unstable side of minisatellite arrays. Dynamic evolution of megasatellites in yeasts. This article may be confusing or unclear to readers. H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing. I agree to the terms and conditions.
Minisatellites have been implicated [ citation needed ] as regulators of gene expression e. Jeffreys; Sequences flanking the repeat arrays of human minlsatellites: This article has multiple issues. For the size class of orbiting spacecraft, see miniaturized satellite. This article is also available for rental through DeepDyve. Retrieved from ” https: Since all hypermutable minisatellites contain internal variantsthey provide extremely informative systems for analyzing the complex turnover processes that occur at this class of tandem repeat.
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Hypervariable ‘minisatellite’ regions in human DNA.
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Repeat turnover therefore appears to be controlled by recombinational activity in DNA that flanks the repeat array and results in a polarity of mutation. Thank you for submitting a comment on this article. WikiProject Genetics may be able to help recruit an expert. Please help improve reggions or discuss these issues on the talk page. You could not be signed in. July Learn how and when to remove this template message.
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Minisatellites have been associated with chromosome fragile regins and are proximal to a number of recurrent translocation breakpoints. It has been proposed that minisatellite sequences encourage chromosomes to swap DNA. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide.
You must accept the terms and conditions. Citing articles via Web of Science Please check for further notifications by email. Minisatellites were subsequently also used for genetic markers in regionw analysis and population studies, but were soon replaced by microsatellite profiling in the s. These variant repeats are tandemly intermingled.
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Sign In or Create an Account. Learn how and when to remove these template messages. Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes. Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting mihisatellite chromosomes from damage.
Hypervariable ‘minisatellite’ regions in human DNA.
Abstract We present DNA sequences flanking cloned hypervariable human minisatellites. Somatic changes are suggested to result from replication difficulties which might include replication slippageamong other phenomena. In alternative models, it is the presence of neighbouring double-strand hotspots which uypervariable the primary cause of minisatellite repeat copy number variations.
We present our own findings concerning this hyprrvariable, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function. Such an event would ultimately lead to the extinction of a hypermutable minisatellite by meiotic drive. Oxford University Press is a department of the University of Oxford.
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